Carnosine: Multipurpose Anti-Aging Nutrient
ثبت نشده
چکیده
Carnosine Declines with Age Carnosine (not to be confused with L-carnitine) is found in highest concentrations in long-lived tissues such as skeletal muscle, cardiac muscle and brain.1 Muscle carnosine levels in humans decline 63 percent from age 10 to 70 (Fig. 2).2 This marked reduction in muscle carnosine concentration may be a cause of the age-related decline in muscle mass, strength and function. Stress, infections and trauma also cause carnosine levels to decline, which may help explain the increased mortality in the elderly following stressful events.
منابع مشابه
Kevin Crowley
Carnosine is a dipeptide compound that is found in many dietary supplements and food products. Carnosine has many functions in the body, such as alleviating oxidative stress on tissues by acting as an antioxidant compound. Carnosine, therefore, has important anti-aging properties. Carnosine is also capable of forming protective sequestration structures around heavy metal ions; this process of c...
متن کاملUse of carnosine as a natural anti-senescence drug for human beings.
Carnosine is an endogenous free-radical scavenger. The latest research has indicated that apart from the function of protecting cells from oxidation-induced stress damage, carnosine appears to be able to extend the lifespan of cultured cells, rejuvenate senescent cells, inhibit the toxic effects of amyloid peptide (A beta), malondialdehyde, and hypochlorite to cells, inhibit glycosylation of pr...
متن کاملCarnosine and protein carbonyl groups: a possible relationship.
Carnosine has been shown to react with low-molecular-weight aldehydes and ketones and has been proposed as a naturally occurring anti-glycating agent. It is suggested here that carnosine can also react with ("carnosinylate") proteins bearing carbonyl groups, and evidence supporting this idea is presented. Accumulation of protein carbonyl groups is associated with cellular ageing resulting from ...
متن کاملCarnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling
Carnosine (β-alanyl-L-histidine), described as an enigmatic peptide for its antioxidant, anti-aging and especially antiproliferation properties, has been demonstrated to play an anti-tumorigenic role in certain types of cancer. However, its function in human gastric carcinoma remains unclear. In this study, the effect of carnosine on cell proliferation and its underlying mechanisms were investi...
متن کاملApplication of Carnosine Patch Improves Cellular Physiological Status in Different Organs
Carnosine (β-alanyl-L-histidine) was first isolated from meat extracts by Russian scholars in 1900. Carnosine is now recognized as an anti-aging chelator/antioxidant with non-enzymatic free radical scavenging properties and serves as an immunomodulator and neuroprotector molecule. It is a naturally-occurring (endogenously synthesized) dipeptide present in brain, cardiac muscle, stomach, kidne...
متن کامل